The principles of amniotic fluid embolism management are to maintain vital signs and protect organ function. Once the amniotic fluid embolism occurs, it is more critical and needs to be treated in every second, and joint multidisciplinary treatment is needed. The main principles of treatment are as follows: 1) ensure the airway is unobstructed, administer oxygen to the pregnant woman by mask, and if necessary, tracheal intubation is needed to ensure oxygenation; 2) maintain hemodynamic support, which requires cardioplegia, relief of pulmonary hypertension, anti-shock treatment, anti-allergy treatment, and correction of coagulation dysfunction. Because of amniotic fluid embolism, coagulation dysfunction will appear soon, so plasma, cold precipitation and fibrinogen should be infused as soon as possible; 3. If the amniotic fluid embolism occurs before delivery but cannot be delivered as soon as possible, the pregnancy should be terminated by cesarean section as soon as possible. In case of coagulation disorders after termination of pregnancy, the uterus must be decisively removed in case of massive bleeding. However, if the uterine bleeding is low, it is not necessary to remove the uterus, but it is necessary to analyze the situation on a case-by-case basis.