When a couple has been married for many years without having children, it is not necessarily the woman’s problem, but it can also be caused by the man’s infertility. There are many causes of infertility in men, such as abnormal reproductive organs, endocrine abnormalities, infectious factors, environmental factors, medication and surgical factors, and many other causes. Male reproductive organ abnormalities can directly lead to infertility, such as congenital azoospermia, varicocele dysplasia, XYY syndrome, and male pseudohermaphroditism. Abnormal testicular descent is also an important cause of male infertility, and varicocele and androgenic target organ lesions can lead to male infertility. If the male endocrine abnormalities will occur in the body androgen reduction thus causing sexual dysfunction, such as decreased libido, erectile dysfunction, non-ejaculation and retrograde ejaculation, resulting in the normal ejaculation of semen into the vagina, etc., is also one of the factors that cause infertility. Infectious factors are also important causes of male infertility, such as mumps virus can cause testicular inflammation, and in severe cases, permanent destruction and atrophy of the varicocele and testicular failure, leading to infertility. Sperm damage in men who are exposed to environmental pollution or radioactive environments, and a continuous decline in the quality and quantity of sperm is also a cause of infertility. Male infertility can be caused by taking certain drugs, such as isoniazid, or because of certain surgeries, such as hernia surgery, which can harm the vas deferens. In short, the causes of male infertility are very many, as to what is the specific cause, need to go to the hospital to improve the relevant aspects of the examination to be able to confirm the diagnosis, after the diagnosis of timely treatment, usually have a good attitude.