Hepatitis B virus DNA 1.25 * 10 three times, suggesting that the body is infected with hepatitis B virus, the viral load of medium level, infectious, the severity of the need to continue to do the liver function and other tests to determine the synthesis. Hepatitis B DNA 1.25 * 10 three times, suggesting that the body is infected with hepatitis B virus, may be hepatitis B patients or hepatitis B virus carriers, with a strong infectious. The higher the quantitative value of Hepatitis B DNA, the higher the number of Hepatitis B virus in the body and the more active the virus replication. If liver function transaminases are significantly elevated, combined with hepatitis B DNA quantitative replication of moderate or above, clinical antiviral treatment with entecavir, interferon, tenofovir and so on is usually required. If the liver function is normal, follow-up observation is usually sufficient. Hepatitis B virus DNA 1.25*10 in the third degree, it is recommended to consult the Department of Infectious Diseases for further management.