Faced with the ultrasound and CT examination reports showing nodules or substantial occupying lesions found in the liver, many people are frightened, anxious and overwhelmed. It is undeniable that tumors account for a large part of the substantive occupying lesions found in the liver, including primary liver cancer, metastatic liver cancer, liver sarcoma, bile duct cancer, hepatic hemangioma, liver fibroids, etc. However, nodules (occupancies) in the liver are definitely not all tumors, and not all of them are malignant tumors! Besides tumors, there are many other diseases with similar manifestations, such as nodules of cirrhosis, liver cysts, liver abscesses, liver cysticercosis, liver cysticercosis, etc., and also uneven fatty liver, so there is no need to be afraid of the liver occupancy. A female patient I treated had a cyst in her liver the size of an eggplant on ultrasound examination, which was later extracted by ultrasound-guided puncture with over 500 ml of clear fluid. Another patient had a fever that was not effectively treated with various antibiotics, and a 5 cm diameter swelling in the liver on CT examination was confirmed to be a liver abscess after CT-guided aspiration of reddish-brown pus, which was treated with drainage, irrigation and medication with excellent results, and the temperature came down the same day. Each lesion has its own characteristic signs, and the vast majority of diseases can be diagnosed with the available technical means. Let’s learn together about the common diseases of intrahepatic nodules and how they differ from each other. Hepatic hemangioma, consisting of blood-filled, dilated blood sinuses, is a common benign tumor of the liver. Patients with asymptomatic or mild symptoms and a long, slow-growing course have a good prognosis, and can be clearly diagnosed with ultrasound and CT examinations. For hepatic hemangioma with atypical performance, ultrasonography of the liver can be considered, with a diagnostic accuracy of 94%. There is no need to panic and fear when hepatic hemangioma is found. If it is less than 5cm, no treatment is needed, and it should be monitored every 3-6 months. Cirrhotic nodules are more common and their size is related to their etiology and pathological typology. Most of them are post-hepatitis cirrhosis in China, and a few are alcoholic and schistosomal cirrhosis. There is extensive hepatocyte necrosis, nodular regeneration of residual hepatocytes, connective tissue proliferation and fibrous septum formation, leading to structural destruction of liver lobules and pseudobullet formation. Small nodular cirrhotic nodules are relatively uniform in size, while large nodular cirrhotic nodules vary in size up to 75 px. cirrhotic nodules do not have the vascular changes of hepatocellular carcinoma and can be differentiated by CT plain and enhanced images. Heterogeneous fatty liver can also show low-density occupancy or nodules, and B-ultrasound and CT examination can make a clear diagnosis. If there is still doubt, liver aspiration biopsy will be the final word. Hepatic adenoma: often without a background of liver disease, more females, often with a history of oral contraceptive use, is not easily distinguished from highly differentiated hepatocellular carcinoma. A more meaningful test for differentiation is 99mTc nuclide scan. Hepatic adenoma is capable of uptake of nuclide and shows a strong positive image in delayed phase. Hepatomegaly: The liver is progressively enlarged, hard and nodular in texture, and in the late stage it may resemble liver cancer. However, the disease generally has a long course and progresses slowly. The intracutaneous test is a specific test, and ultrasound and CT examinations can reveal floating cysts, sometimes with calcified head nodes in the cyst wall. Some patients may find intrahepatic occupying lesions ≥2 cm in diameter, or increased single serum alpha-fetoprotein (AFP), while other indicators do not meet the diagnostic requirements to establish the diagnosis (because the diagnosis of liver cancer is very serious, doctors cannot blindly and hastily make the diagnosis without sufficient evidence), and patients may be apprehensive and frightened at this time. For this situation, further testing of serum tumor markers, MRI with high tissue resolution can provide valuable additional information and help to make a clear diagnosis; ultrasound or CT guided puncture of suspicious nodes for pathological examination, which is the gold standard of liver cancer diagnosis! This is how many of our patients get early diagnosis and early treatment. Selective hepatic arteriography can clearly show small lesions in the liver and their blood supply, while treatments such as chemotherapy and iodine oil embolization can be performed. This technique allows for both diagnosis and treatment, combining the two into one and performing them simultaneously. It can be used for patients who cannot be diagnosed after other tests, and it can serve as an “arbiter”, so that it is clear whether it is or is not. If it is liver cancer, it can be treated at the same time, and if it is not, it can clear the patient’s doubts and allow him/her to put down the burden and live easily.