Clinical study of 120 cases of epidermal growth factor receptor antagonist-associated rash treated with Chinese herbal medicine ZY-06 Wang Hongyan2, Zou Chao3, Cui Huijuan2#, Wang Wei2, Jiao Shunchang4, Li Junling5 (1 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;2 China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China;3 Beijing University of Chinese Medicine, Beijing 100029, China;4 PLA General Hospital, Beijing 100853;5 Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021) Abstract: Objective: To observe the efficacy of topical application of heat-clearing and dampness-reducing Chinese medicine (ZY-06) in the treatment of acne-like rash associated with epidermal growth factor receptor antagonists and to evaluate the safety of the drug. METHODS: Patients with malignant tumors who developed acne-like rash after the application of epidermal growth factor receptor antagonists with clear pathological diagnosis were selected. 120 patients were randomly divided into 80 cases in the treatment group and 40 cases in the control group. 40 cases. The treatment was applied externally and erythromycin ointment was given to 40 patients in the control group for 14 consecutive days. The patients in both groups underwent routine blood and liver and kidney function tests to evaluate the safety of the drug before and after administration. The acne-like rash and pruritus in both groups were relieved to different degrees. By comparing the grading of acne-like rash and pruritus in both groups after treatment, the P value was less than 0.05 by SPSS16.0 statistical software analysis, which was statistically different. The results of efficacy evaluation, acne-like rash: 57 effective cases and 23 stable cases in the treatment group; 7 effective cases and 33 stable cases in the control group; pruritus: 45 effective cases and 35 stable cases in the treatment group; 3 effective cases and 37 stable cases in the control group. The SPSS7.0 statistical software analysis showed that the P value was <0.05, which was statistically different. No significant hematological toxicity was observed in both groups through routine blood and liver and kidney function tests before and after drug administration. No adverse reactions related to topical medication were observed in either group. Conclusion: The distribution of the number of patients with acne/acne-like rash and itching in the two groups before and after treatment showed that the acne-like rash and itching were significantly relieved after the application of ZY-06, and its efficacy was better than that of erythromycin ointment. In addition, the safety assessment of 120 patients before and after treatment showed that ZY-06 had good safety. This indicates that ZY-06, a heat- and dampness-clearing herbal medicine, is effective in improving acne-like rash and pruritus associated with epidermal growth factor receptor antagonists without significant adverse effects, and can play a role in escorting epidermal growth factor receptor antagonists in the treatment of tumors.