The effects of premature ovarian failure and diagnostic criteria Premature ovarian failure is a common gynecological endocrine disorder in women of reproductive age, which can lead to abnormal menstruation, menopausal symptoms, infertility, as well as earlier onset of osteoporosis and cardiovascular disease. Therefore, early diagnosis and timely treatment are very important. Diagnostic criteria: 4 to 6 months or more of menopause and a hormone test with follicle stimulating hormone greater than 40 U/L. Treatment of Premature Ovarian Failure Hormone supplementation is the treatment of choice for premature ovarian failure. Specific medications: Generally, it simulates the normal menstrual physiological cycle with estrogen and progestin for 10 to 14 days per month. One of the specific regimens: oral supplementation with Glivec 2 mg daily, with the addition of a daily dydrogesterone tablet of 10 mg starting 11 days after dosing, with 21 days of discontinuation and 7 days of discontinuation before starting the next cycle of treatment. Hormone supplementation is generally recommended and should be used at least until the patient’s normal age of menopause, after which she is treated as a woman who has menopause at a normal age.