The term occipital nerve block refers to occipital large nerve block, which is used clinically for the treatment of cervicogenic migraine, other causes of headache, herpes zoster and its postherpetic neuralgia, and other disorders. Occipital large nerve block is mainly used to treat headache by injecting glucocorticoid and anesthetic drugs, usually under the guidance of imaging monitor. The location of the injection is first determined, usually at the line between the mastoid process and the atlantoaxial joint, and the patient may experience an abnormal sensation when the injection touches the greater occipital nerve. After adequate aspiration, the drug is injected either superiorly or inferiorly to the capitellar tendon membrane. It should be noted that when the occipital nerve block is performed, the injected drug should be insisted on suction to avoid the anesthetic entering into the occipital artery, and the wound should be protected to avoid infection after the operation.