This article is written with the feeling that we are seeing an increasing number of elderly people with pain due to osteoporosis in clinical practice. Osteoporotic bone pain is a common systemic metabolic disease. In short, it is pain that has its roots in osteoporosis. The root of the disease is osteoporosis, and only by treating osteoporosis can we get to the root of the problem and eliminate the pain. The specific form of the disease can be manifested in the following areas: 1. Severe osteoporosis occurs in the spine, the most common site is the thoracolumbar segment combined (here is the most concentrated structural stress) T12, L1 vertebrae. This is manifested by collapse and flattening of the vertebral body in the form of a millstone concavity. This condition often irritates the intercostal nerves, causing pain in the back and anterior abdomen along the course of the intercostal nerves. 2. Lesions occurring at the point of attachment of the tendon to the lax bone, leading to significant tendonitis and periostitis, manifesting as severe pain. The above two conditions are the most common sites of painful action associated with osteoporosis. Clinically, they often manifest as pain during postural changes. After clarifying the two common pain sites and pathogenesis, the next direction of treatment is clear. That is to treat both the symptoms and the root cause. The symptom is: “pain”. The root is “osteoporosis”. To treat the pain, we can inject anti-inflammatory and analgesic drugs at the nerve roots. The treatment of osteoporosis can be in accordance with the “calcium triad” to scientific treatment.