How do I know when hypoglycemia occurs at night? Hypoglycemia can occur at night when diabetic patients are asleep, but it is the least detectable at this time. Hypoglycemia at night is often very dangerous, and some people may even lose their lives in their sleep because of hypoglycemia. So how can we know that hypoglycemia has occurred at night? Nocturnal hypoglycemia often has the following symptoms: nightmares, sweating (sweating wet clothes), morning headache, and weakness. When the presence of nocturnal hypoglycemia is suspected, the determination of fasting blood glucose is unpredictable, and blood glucose should be tested at 2 to 3 o’clock at midnight the next day. After the hypoglycemia is confirmed, the evening insulin dose can be adjusted by adding a small amount of meal before bedtime or under the guidance of a doctor. What measures should be taken in case of hypoglycemia? If hypoglycemia is suspected, blood sugar should be measured to confirm the diagnosis; if blood sugar cannot be measured, it should be treated as hypoglycemia. 1. Awake patients: immediately give oral sugar, such as sugar cubes or liquid glucose (usually 15-30g), and measure blood glucose after 15 minutes; if not corrected, continue to supplement. Hypoglycemia caused by long-acting sulfonylureas (or long-acting insulin) may last longer, so patients taking oral glibenclamide (also called euglycemia) should have their blood glucose tested for 24-48 hours after waking up. Sometimes patients may need to give glucose intravenously for a long time and therefore need to be hospitalized. 2. Patients who are not awake: give 20-40ml of 50% glucose solution intravenously; give oral glucose as soon as the patient is awake. Hypoglycemia caused by long-acting sulfonylureas (or long-acting insulin) may last for a long time. Therefore, it is very important that blood glucose should be tested for at least 24 hours after the patient is awake.