The saturation and concentration of uric acid in the body at 37℃ is about 420μmol/L (7mg/dl), above this concentration is hyperuricemia, and long-term hyperuricemia may lead to gout. The prevention and treatment of primary hyperuricemia mainly includes the following aspects: 1. General treatment: control the total calories in the diet; limit the consumption of alcohol and high purine food; drink a lot of water to increase the excretion of uric acid; use drugs that inhibit uric acid excretion such as thiazide diuretics with caution; avoid triggering factors and actively treat related diseases. 2.Treatment of hyperuricemia: mainly include uric acid excreting drugs such as benzbromarone, drugs that inhibit uric acid production such as allopurinol, alkaline drugs such as sodium bicarbonate, new uric acid lowering drugs such as selective uric acid reabsorption inhibitors, etc. 3.Treatment of acute gouty arthritis period: after hyperuricemia develops into gout, colchicine, non-steroidal anti-inflammatory drugs and glucocorticoids are the first-line drugs for the treatment of acute gouty arthritis and should be used early. Treatment of intermittent and chronic gout attacks: for patients with frequent attacks of acute gouty arthritis, chronic gouty arthritis or gout stones, uric acid-lowering therapy should be performed. 4. Treatment principles for secondary hyperuricemia: actively treat the primary disease; try to avoid or reduce the use of drugs and methods that may trigger and/or aggravate hyperuricemia; control the acute gouty arthritis attack as soon as possible. Therefore, the treatment of uric acid reduction should be based on the patient’s specific situation and the corresponding treatment plan should be selected, and the combination of drug therapy and general therapy should be insisted.