Recently, several patients with post-laser hyperpigmentation came to the clinic, all of whom had hyperpigmentation about a month after the laser. Compared to their previously white and clean faces, their faces had become dull and unevenly pigmented, and in some cases, unevenly pigmented. Many patients asked why this happened, but the laser therapist said he would guarantee that no hyperpigmentation would occur. After a detailed follow-up of the medical and treatment history, most patients choose fractional CO2 laser instead of other fractional lasers. Carbon dioxide fractional laser rejuvenation and wrinkle removal, and treatment of acne pits, has very good results, especially in the European population, which is white, with one treatment and multiple treatments that will significantly rejuvenate the skin. However, if Asians and other colored people, using this laser treatment for facial diseases or skin rejuvenation, the biggest problem is easy to appear pigmentation, according to the information reported, the Asian people can reach about 40% of the color sink, women above forty years old, because of melasma or other factors, more likely to appear pigmentation, the chances will be higher. Therefore, nowadays, experienced dermatologists rarely use CO2 fractional laser to treat facial diseases. Currently, there are very many types of lasers on the market, each with its own unique working principle and target cells, acting at different skin depths, so there are different indications. Not only do patients not know much about them, but also many dermatologists, to put it politely, do not know much about the types of lasers and their indications. There are many kinds of lasers for the treatment of acne pits, divided into two categories. The first category is non-invasive lasers such as fractional 1550 glass laser, fractional 2970 laser, fractional 1320/1440 laser, etc. These lasers, which have no damage to the skin or are only minimally invasive, rarely show pigmentation. laser, fractional 2940 laser, plasma, etc. The latter two are relatively safe, and the skin is peeled off in thousands of layers, and pigmentation rarely occurs. No matter what kind of laser you choose to treat acne pits, you should first avoid the area where the original skin discoloration occurs such as melasma; seborrheic skin rarely shows discoloration, and by the same token, if the skin is properly moisturized and treated after laser treatment, the chance of discoloration should be relatively rare. Sometimes moisturizing is more important than avoiding light and repairing. Post-operative care is critical, laser selection is critical, and skin type selection is critical. It is important to analyze each patient’s skin type, whether they have primary hyperpigmentation or melasma, whether they work outdoors, whether they have a family history, whether they have been exposed to the sun, whether they have red blood cells, whether they have sensitive skin, etc. It is important to choose different lasers according to individual skin types to receive good results and to avoid hyperpigmentation to the greatest extent.