With the development of imaging techniques such as magnetic resonance imaging, the diagnosis of glioma has now become relatively easy. However, not all patients are able to detect the disease in time and go to the hospital for examination in the early stage of the disease, but come to the hospital when the tumor is already large in size. Below I have introduced five common early clinical symptoms of glioma. 1.Headache About 30% of glioma patients show headache, and about 70% of them have headache which will gradually worsen. Most of these headaches are not specific, but are intermittent, mostly located on the same side of the lesion, and are dull pains rather than throbbing pains, sometimes not easily distinguished from tension headaches. Gliomas of the brain usually present as pain in the forehead, while gliomas of the cerebellum tend to present as pain in the occipital and neck areas. If the tumor is too large and produces high cranial pressure, the headache is significantly worse, sometimes waking up with pain during sleep and significantly worse with vigorous head movements, sometimes accompanied by nausea and vomiting. If the intracranial hypertension lasts for a long time, there will also be the manifestation of vision loss. 2. Mental changes About 15-20% of glioma patients have mental status changes as the first symptom, mainly in mood, personality, cognitive function, memory and other changes. 3.Focal neurological symptoms Different locations of tumor may also cause corresponding neurological deficiency symptoms, such as paralysis of limbs, sensory impairment, aphasia, unstable gait, loss of reading and writing, etc. 4.Cranial nerve symptoms Different cranial nerve damage will produce corresponding neurological symptoms, such as vision loss, diplopia, eye strabismus and facial palsy. 5.Seizures About 1/3 of patients with glioma show seizures, and the incidence increases to 50-70% during the progression of the disease. Of these, half of the seizures are limited seizures, while the other half are generalized seizures. Slow-growing, low-grade gliomas are particularly likely to cause seizures, while glioblastomas are much less likely to cause seizures. Overall, gliomas can present with all the symptoms of neurological disease, but not all of them will be present in a particular individual, and these early symptoms will vary with the type of tumor, tissue characteristics, and the location and rate of growth. It is important to visit the neurosurgery department of the hospital as early as possible if you experience the associated obvious symptoms.