Neuroblastoma is a very common malignant solid tumor in pediatric patients, with a high degree of malignancy and a high risk to pediatric life. However, the natural regression of neuroblastoma is interesting. On the one hand, it is bad, progressing and metastasizing, leading to the death of the pediatric patient; on the other hand, it can regress on its own; there is another regression to benign differentiation. Our experience has been that neuroblastoma – ganglioblastoma – ganglioblastoma. The older the child is, the better the tumor differentiation is relatively, the closer to normal. However, surgical resection of ganglioblastoma is difficult even if pathologically confirmed as benign. This is because although it is now benign, it is initially malignant and it will infiltrate into the surrounding tissues, especially the blood vessels. So the difficulty of surgical resection is the same as that of malignant neuroblastoma.