The traditional treatment for hepatocellular carcinoma is surgical resection, and for patients who are not suitable for surgical treatment, interventional embolization is used. However, most patients with hepatocellular carcinoma have lost the chance of surgery when they are found, and interventional embolization has the disadvantages of easily damaging the normal liver, having large side effects and being prone to recurrence after treatment. It is still not ideal for older patients with poor physical condition and larger lesions. After our clinical practice, it is confirmed that ultrasonic focused knife + radioactive particle implantation is a good treatment for liver cancer. Firstly, we apply high-intensity focused ultrasound knife with non-invasive characteristics, using the good focus of ultrasound and permeability of energy to effectively irradiate liver tumors and irreversibly kill tumor cells by using instant local high temperature (70℃-110℃) without damaging normal tissues. After ultrasonic knife treatment, on the basis that the tumor is mostly killed, the tumor lacks blood supply and the risk of needle tract metastasis caused by puncture is reduced, then particle implantation treatment is used to further improve the local treatment effect. Because liver cancer cells are sensitive to radiation, radioactive particles are directly implanted in the tumor with obvious killing effect, and at the same time, because of the close irradiation, the impact on surrounding normal tissues is minimal. Therefore, the combined application of these 2 minimally invasive techniques for the treatment of liver cancer is reliable, with low side effects and short treatment time. Since it is a minimally (non-)invasive treatment, it is easily tolerated by patients. It is especially suitable for patients who are older, weaker, have larger lesions and have residual recurrence after interventional embolization treatment. Radioactive particle implantation + ultrasound focused knife minimally invasive treatment is a good treatment for liver cancer and provides new hope for liver cancer patients.