Gallstone disease includes stones that occur in the bile ducts and gallbladder. Asymptomatic stones can be observed and followed up first, but for symptomatic patients, gallstones are still primarily treated surgically. For symptomatic and/or complicated gallbladder stones, cholecystectomy is preferred and laparoscopy has become the “gold standard” for gallbladder stones. Extrahepatic bile duct stones require surgical treatment, especially if they are associated with biliary obstruction, biliary infection with lesions, etc., and require common bile duct exploration. Surgery is generally not required for asymptomatic stones, but surgery should also be considered for the following asymptomatic gallbladder stones: 1. large number of gallbladder stones with small size, easily falling into the common bile duct; 2. gallbladder stones ≥ 2-3 cm in diameter; 3. gallbladder full of stones or gallbladder atrophy; 4. gallbladder neck stones embedded; 5. gallbladder calcification or “porcelain bottle-like ” gallbladder; 6, and gallbladder polyp-like lesions; 7, greater than 3mm with cholecystitis gallbladder wall thickening. In short, if you have gallstones, it is recommended to consult a medical professional and undergo surgery when you meet the indications for surgery.