1. Background of the study: In recent years, instead of using BMD alone to diagnose and assess patients’ likelihood of fracture in the next 10 years, WHO has recommended the use of fracture risk factor instrument (FRAX) to assess the degree of osteoporosis. One reason for this is that the 10-15% difference in peak bone mass between yellow and white populations causes the WHO diagnostic criteria for osteoporosis (T value ≤ -2.5 SD) to tend to increase the underdiagnosis rate in the Chinese population. The Fracture Risk Factor Instrument (FRAX) is based on the analysis of a series of data from evidence-based medical studies on a number of fracture risk factors and/or BMD values, combining the probability of fracture with multiple clinical risk factors and bone mineral density (BMD) of the femoral neck. FRAX has been widely used in clinical practice in Europe, the United States and Latin America, and the WHO has proposed a prospective project to strengthen FRAX research in order to further promote FRAX research and to find a suitable diagnostic threshold for the Chinese population. Zhang Zhihai, Department of Orthopaedics, Aviation General Hospital of China Medical University 2, research project design content: 1), expected sample size: 50,000 people, half of each sex; project duration: 3.5 years; sample follow-up time of 3 years, half a year for data addendum, statistical analysis and thesis preparation; sample test BMD and calculate FRAX value 6 times, every six months testing; sample age grouping: 40-49, 50-59, 60-69, 60-69, 60-69, 60-69, 60-69, 60-69, 60-69, 60-69, 60-69. 50-59, 60-69, 70-79, 80-; measurement site: femoral neck, etc. 2), participating hospitals/medical institutions: 30-50, one person in charge of each, self-organized team; 3), detection of bone density equipment: various types of DXA detection equipment (including LUNARHOLOGICNORLAND and other equipment) to obtain BMD results can be directly substituted into FRAX for 4), the start of the study and every six months after the submission of a list of sample results and follow-up reports; 5), FRAX to obtain the results and basic information: http://www.sheffield.ac.uk/FRAX/?lang=chs, the same site can be obtained from the computer version of the FRAX tools and iphone version of the FRAX software ; 6), Each sample needs to register items: age, sex, date of birth, height (cm), weight (kg), history of previous fracture (with or without), history of parental hip fracture (with or without), current smoking behavior (with or without), history of adrenocorticotropic hormone use (with or without), history of rheumatoid arthritis (with or without), history of secondary osteoporosis (with or without), intake of more than 3 units of alcohol per day (with or without) Femoral neck BMD value, each FRAX calculation result, follow-up of all samples with or without fracture occurrence in 1.5 years, indicating the fracture site and calculating the actual fracture incidence; 7), samples younger than 40 years old were excluded; 3. Research subject rights: 1), the Chinese Journal of Osteoporosis society is responsible for supervising and coordinating the implementation of this subject, timely release of research progress to all participating research units at regular intervals, responsible for publishing each 1) The Chinese Journal of Osteoporosis is responsible for supervising and coordinating the implementation of the project, releasing the research progress to all participating research units on a regular basis, publishing each paper, and recommending excellent papers for publication in the International Osteoporosis Foundation (IOF, International Osteoporosis Foundation) and WHO-affiliated SCI journals; 2) Each participating medical institution publishes its own FRAX prospective study as the first author; all data rights and interests are shared among the participating research units and can be used mutually; 3) 3) The report of each stage of the study and the results were submitted to the relevant scientific management department of WHO for certification; 4) The FRAX assessment tool threshold standards were formed in mainland China and signed by all participating research units.