Four major problems in treating craniopharyngioma 1, craniopharyngioma is prone to recurrence Although craniopharyngioma is a benign tumor, it is different from ordinary benign tumors in that it does not have a peripheral membrane, and it has the characteristics of invasive growth. Although it has been completely resected under the microscope, there are still a very small part of tumor cells remaining, which may cause tumor recurrence in the later stage. Craniopharyngioma is not sensitive to radiation therapy and chemotherapy, and the difficulty of treatment will be further increased once it recurs. 2.Craniopharyngioma is not easy to be found in the early stage. Craniopharyngioma is a rare intracranial tumor, which can develop in all ages, and it is often neglected and cannot be found in time when patients start to have symptoms. A common symptom in patients with craniopharyngioma is vision loss. When school-age children suffer from vision loss, parents firstly think of nearsightedness and go to get glasses; after getting glasses, children’s vision still decreases, and ophthalmological examination reveals optic nerve atrophy before they think of intracranial tumors, which delays the time of treatment. 3 years old or less children’s vision loss is difficult for parents to notice, and some of them will not be discovered until they become completely blind. 3.Hypopituitarism after resection of craniopharyngioma is a world problem Almost all craniopharyngiomas have hypopituitarism after complete resection or active resection, which is manifested as polydipsia and polyuria, hypoadrenocorticism, hypothyroidism, hypoactive gonadotropic hormone, and metabolic disorders. Hormone replacement therapy after surgery is an important means to ensure the patient’s life safety. Some patients with craniopharyngioma have good spirit in the first 2 days after removing the tumor, but then they have depression, electrolyte disorder, endocrine disorders, and if they can’t be handled correctly, the patients’ lives will be in danger. 4, deep location of craniopharyngioma makes surgery difficult. The most common location of craniopharyngioma is in the saddle area, which belongs to the center of cranial brain and is deep in location and surrounded by optic nerve, internal carotid artery, anterior cerebral artery, pituitary gland, hypothalamus and other major structures, and craniopharyngioma is often adhered to the hypothalamus. If the optic nerve is damaged during surgery, it can lead to vision loss and even blindness. Damage to the internal carotid artery or anterior cerebral artery can cause hemorrhage and be life-threatening. Damage to the hypothalamus and pituitary gland will result in hypopituitarism and endocrine disorders, which will cause poor physical condition and resistance of the patient in mild cases, and life-threatening in serious cases. The difficulty of surgery for craniopharyngioma lies in the need to completely remove the tumor as much as possible to prevent recurrence of the tumor, while avoiding the damage of the surgery to the important structures around the tumor.