Craniopharyngioma is a congenital tumor, accounting for about 5% of intracranial tumors, and is more common in children and adolescents, with more males than females. Craniopharyngioma is located in the saddle region, and its growth causes pressure on the adjacent pituitary gland, pituitary stalk and hypothalamus, causing dysfunction of these structures, which is clinically manifested as headache, apathy, visual acuity and visual field disorders, water and electrolyte disorders (polydipsia and polyuria), poor appetite, weak physique, dry and white skin with little sweating, short stature, obesity, and delayed development of the secondary sexual characteristics of children. Once diagnosed, should be early surgery, strive for total resection or near-total resection, postoperative adjuvant radiotherapy, can make the child get long-term survival. 1.Postoperative observation If the child undergoes tumor resection under general anesthesia, the child should be treated according to general anesthesia postoperative care, with continuous oxygen intake, close observation of the condition changes, cardiac and electrical monitoring of vital signs, head elevation of 30 °, and detailed records of the condition. According to the operation area drainage and ventricular drainage routine care, 48h to remove the operation area drainage tube, ventricular drainage tube about 3-5 days to remove, wound 7-8 days to remove the stitches. 2, postoperative infusion Follow the doctor’s instruction to check the blood electrolytes, and adjust the type and quantity of infusion according to the check of blood sodium, blood potassium and urine volume. During the infusion process, closely observe the condition to prevent the child from having epilepsy and coma when the blood sodium is too high or too low. If mild epilepsy occurs, luminal sodium 0.1gq8h can be injected intramuscularly. General postoperative routine application of dexamethasone 5-10mg added to the liquid intravenous drip, in order to prevent hypopituitarism leading to a decrease in hormone levels, to prevent laryngeal edema. 3, close monitoring of vital signs in the nursing process Postoperative children may have mild agitation, such as hallucinations, hallucinations and other psychiatric symptoms, should be placed in the guardianship room for special monitoring, close observation of changes in vital signs, and timely treatment of problems found. Keeping the airway open requires timely suction. Children with nebulized inhalation in the trachea, 2 times a day, to prevent lung infection. 4, skin, oral care Daily bath with warm water, turn over on time, keep the bed sheet flat, clean, prevent bed sores. Oral care 3 days after surgery, twice a day, lip oil on lips to prevent dryness and cracking, to prevent blistering of lips during postoperative fever. 5, psychological and health guidance (1) take medication on time and in accordance with the amount of surgery for total resection, the prognosis is better. Due to the surgery will produce a certain degree of damage to the hypothalamus, there will be endocrine changes for a long time after the operation, for the urinary avalanches, we should ask the children to take long-acting urinary avalanches or micoagulant tablets orally, and review regularly. Sometimes children also appear obesity symptoms, need to take thyroxine, growth hormone, when the child’s age is close to puberty, need to use sex hormones to promote the development of secondary sexual characteristics. The use of various hormones as prescribed by the doctor can make the child’s body and sexual characteristics develop normally. (2) Maintaining a stable mood of the child explains the importance of maintaining a good and stable mood to promote health, and try to create a good environment for recuperation during the recovery stage of the disease. (3) Enhance the child’s nutrition due to surgical trauma, energy consumption, and the child is in the stage of growth and development, should be given a comprehensive diet, strengthen the high protein, high calorie, high vitamin, easy to digest diet to promote recovery. Since the children are young, the nursing staff should often go deep into the wards according to the growth and development characteristics of adolescents and children, and care for and consider the children with a gentle attitude and tone of voice.