HPV is the abbreviation of human papillomavirus, which is divided into two types: high-risk and low-risk. HPV16 is a high-risk HPV infection, which is one of the most carcinogenic types of HPV infection. HPV is a spherical DNA virus, and infection with HPV16 high-risk positive virus commonly manifests clinically as common warts, flat warts, genital warts, etc. Some high-risk HPV types may even lead to cervical cancer, anal cancer and other malignant tumors. If the test results show that the HPV16 virus has been infected, there is often no obvious clinical discomfort at the beginning and can be observed regularly for a period of time, and the HPV16 virus can be cleared by the autoimmune system in some patients. However, if patients have uncomfortable symptoms, such as abnormal increase in leucorrhea, bloody leucorrhea, abdominal pain, cervical contact bleeding, etc., they need to apply medications such as fluorouracil or alpha-interferon under the guidance of doctors, or take physical treatment methods such as freezing, laser, electrocautery, etc., and if necessary, surgical excision treatment. In addition, it is worth noting that HPV is a contagious disease that can be transmitted through sexual contact, contact with the infected person’s household goods, medical source infection, mother-to-child transmission, etc. Isolation and protective measures should be done. If HPV infection occurs, the partner should be treated at the same time. The risk of HPV infection can be clinically reduced by HPV vaccination, therefore, HPV vaccination is recommended for women of appropriate age. If there is no need to have children, it is recommended to wear condoms during intercourse.