Uterine factor infertility refers to infertility caused by the loss of the ability of the female uterus to obtain or maintain a pregnancy for anatomical or physiological reasons. Uterine factors account for approximately 3-5% of causes of infertility. Surrogacy or cuddling is the traditional approach and uterine transplantation is a possible new option. Although animal models have shown encouraging results, human uterine transplantation is limited to case reports and there are no reports of successful pregnancies after uterine transplantation. Uterine transplantation is difficult and intricate. Ethical issues are equally worth exploring. There is no significant increase in the rate of offspring malformations after organ transplantation, but there is a mild increase in the incidence of preterm birth and gestational hypertension, and a decrease in neonatal birth weight. nTPR and other reports endorse the continued use of immunosuppressive drugs during pregnancy. Patients were socially and spiritually motivated to participate in the study. Participants must be aware of the risks and the very low success rate. 1st human uterus transplant in 2000, removed without pregnancy. The Swedish team has performed 9 human uterine transplants after more than 10 years of research and has reported 1 successful delivery and several other successful pregnancies. Our first domestic uterus transplantation has been performed at Xijing Hospital. Uterus transplantation or surrogacy technology can solve the uterine infertility problems that are currently plaguing everyone, mainly uterine malformation or absence, uterine adhesions, and endometrial damage.