The treatment of neurasthenia often uses a combination of medication, psychotherapy and physical therapy, which is more effective and allows patients to reach a state of cure. Pharmacological treatment for neurasthenia patients can use antidepressants, anxiolytics, sedative-hypnotics, brain nutrients and other drugs as appropriate under the guidance of professional psychiatrists to relieve patients’ tension and treat symptoms such as emotional worries, irritability, sleep disorders, and muscle tension pain. In addition, some Chinese medicinal preparations, such as Guei Spleen Pill, Sour Date Soup, Tianma Hooked Vine Drink, etc. have certain efficacy for patients with neurasthenia, and patients can choose to apply them under the guidance of herbalists for identification. Psychosocial factors are one of the main causative factors for neurasthenia patients, so psychological guidance treatment can transform the mental state of neurasthenia patients, so that patients can establish good confidence in life, full of hope and interest in life, which can often achieve better treatment results and shorten the recovery time of patients. Physiotherapy for neurasthenia patients includes physical exercise, music therapy, travel therapy, electromagnetic therapy, etc. Its can help patients get rid of worrying situations, relieve mental pressure and improve tension, so as to achieve the purpose of treatment. In addition, patients themselves can also promote recovery by adjusting their life and work style and appropriately venting their emotions. To sum up, patients with neurasthenia should adopt the above comprehensive treatment methods under the guidance of a professional psychiatrist to achieve the best treatment effect.