This is a congenital genetic disorder of the nervous system characterized by vascular nevus on one side of the face. Briefly, the disease is a vascular dysplasia of the meninges and facial skin caused by abnormal neurodevelopment during fetal life. It may be related to genetic inheritance, mostly autosomal dominant or incomplete dominant or autosomal recessive, and may also be caused by chromosomal aberrations. The main clinical manifestations are as follows: 1. Skin lesions are facial vascular nevi, mostly located on one side, and occasionally on both sides. They can be found after birth and are red-wine or purplish-red in color, and do not fade when pressed. They are mostly distributed along the 1st and 2nd branches of the trigeminal nerve, and can sometimes spread to the 3rd branch. A few can also be seen in the oral mucosa, neck, trunk or skin of the extremities. 2. Neurological symptoms (1) Seizures: About 90% of patients have seizures. It is mostly manifested as limited convulsions of the limbs contralateral to the vascular nevus. (2) Paralysis: About 30%~50% of the cases have central paralysis on the opposite side of the vascular nevus, which is manifested as inability to hold things, limping and slower development of the lateral limb than the normal side. (3) Intelligent disorders: about 38% of the cases mainly show attention loss, memory loss, language disorders, behavioral changes and low intelligence. 3, eye lesions About 36% to 70% of patients have eye disorders. Among them, 25% have glaucoma since birth. In addition, there may be ocular proptosis, ipsilateral hemianopia, corneal vascular opacity, retinal hemangioma, hypotony, and optic nerve atrophy. Examination: Most of them can be clearly diagnosed mainly by X-ray, EEG, CT and MRI. Treatment: The main treatment is symptomatic. Control epilepsy, treat glaucoma, and prevent vascular hemorrhage. Hemangioma can be surgically removed. Intracranial lesions can be treated with radiation therapy to sclerosis and occlusion. Prognosis: The prognosis is poor, and most of those with severe disease die at the age of 20-30.