The prognosis of hepatocellular carcinoma combined with portal vein cancer embolism is extremely poor, with a natural course of about 2.4-2.7 months, and the treatment is tricky, and there is no ideal and unified standard for treatment; the general treatment means include surgical tumor resection + embolization, combined with chemotherapy pump implantation and transhepatic artery chemoembolization after surgery; portal vein stent implantation, portal vein cancer embolism anhydrous ethanol ablation, or molecular targeted drugs, but the overall treatment efficacy is poor. However, the overall therapeutic efficacy is poor. At present, some domestic patients have applied radiofrequency ablation or chemical ablation to treat portal vein cancer embolism and achieved better therapeutic effect. The patient with advanced hepatocellular carcinoma had severe cirrhosis, a large lesion in the right lobe of liver with unclear boundary and scattered satellite foci, and also combined with cancer embolism in the right branch of portal vein, with no surgical indication, so transhepatic artery chemoembolization (TACE) was performed, and radiofrequency ablation was applied sequentially to ablate the hepatocellular carcinoma and portal vein cancer embolism. The patient is now in good general condition and has survived tumor-free for more than 2 years, and is able to perform his daily life.