In recent years, the incidence of intestinal diseases is on the rise, and according to statistics, 9 out of every 100 people in China are troubled by constipation, the vast majority of which is functional constipation without any organic cause. The main manifestation is a decrease in the number of stools, dry stools or non-dry stools, and poor discharge. It can be accompanied by symptoms such as bloating, abdominal pain, loss of appetite, and regurgitation. Chronic constipation has many hazards, patients due to the effort of defecation and prolonged defecation, will lead to a sharp rise in blood pressure, easily induced cerebral hemorrhage, angina pectoris, acute myocardial infarction, etc., in serious cases, sudden death during defecation. Secondly, constipation can cause or aggravate rectal and anal diseases, such as anal fissures, hemorrhoids, proctitis, ulcers, intestinal perforation, etc., and can induce colorectal cancer, according to information shows that the incidence of colon cancer in people with severe constipation is also significantly higher, can reach 10%. Chronic constipation is not only harmful, the retention of fecal toxins in the body can cause gastrointestinal nerve disorders, interference with brain function induced insomnia, depression and anxiety, the absorption of toxins can also lead to acne, chloasma, acne and other skin problems. As a result of prolonged straining to defecate each time, it causes poor blood circulation in the perineum, leading to sexual disorders and women are prone to dysmenorrhea, etc. Traditional functional constipation mainly uses different types of laxatives to stimulate the intestinal tract, and some patients with persistent constipation even have to resort to surgical treatment. These treatments with stimulating laxatives such as rhubarb and aloe vera as the main ingredients are mainly symptomatic treatment and can only be used temporarily. If taken for a long time, the side effects are great and the therapeutic effect is very limited, easily causing imbalance of intestinal flora, drug dependence, damage to the enteric nervous system, atrophy of intestinal smooth muscle, destruction of intestinal peristaltic function and further aggravation of constipation. The mechanism of intestinal microecology (using probiotics and other therapeutic means) for the treatment of chronic constipation is being gradually revealed, and studies have found that patients with constipation have serious intestinal flora disorders with regularity, and the degree of flora disorders and the hardness of stool are also closely related according to the Brønsted method. With age, the variety and diversity of intestinal flora decreases significantly, and the incidence of constipation gradually increases, and can reach thirty percent among elderly people with constipation. It has been found that by taking probiotic preparations or even daily yogurt has a certain improvement effect on constipation symptoms. Regular supplementation of beneficial intestinal bacteria not only plays the role of optimizing intestinal flora, but also can improve the metabolic environment of the intestine, such as helping the body digest dietary fiber in food, promoting the fermentation of food residues in the colon, softening and loosening the texture of stool, and increasing the production and absorption of short- and long-chain fatty acids, promoting the production of neurotransmitters such as 5-hydroxytryptamine (5-HT) and strengthening intestinal peristalsis, thus further promote the restoration of intestinal function. Recently, a foreign study reported that regulating intestinal flora can promote the regeneration of intestinal pluripotent neural stem cells and repair the damaged intestinal nerves, and the repair of nerves can promote the recovery of contraction ability of colonic smooth muscle, which brings hope for the treatment of chronic intractable constipation. If patients do not have organic intestinal lesions, no cardiovascular disease, diabetes, neurological disease, and repeatedly failed to stimulate intestinal defecation through various treatment pathways, they can go to regular hospitals to carry out the testing and analysis of intestinal microbiome, and experts will make differential diagnosis and symptomatic treatment. The treatment can be carried out by specialists. At present, the Microecology Clinical Research and Treatment Center of Shanghai Tenth People’s Hospital and the Intestinal Function Rehabilitation Specialist of Putuo District People’s Hospital are carrying out the intestinal function rehabilitation treatment based on microecological treatment. According to the difference between the intestinal flora of constipated patients and the flora of normal people, the relevant probiotic preparations can be supplemented to the intestinal tract of patients, so that their beneficial flora can be normalized and the symptoms of constipation can be improved. Probiotic preparations are non-toxic and harmless to the intestinal tract, and through the compounding of multiple strains of bacteria, the limitations of the previous single flora supplementation are also changed. Micro-ecological intervention for intestinal diseases has become a new trend.