With the accelerated pace of life and changes in dietary habits, the incidence of gallstone disease is increasing. The clinical manifestations of gallbladder stones are related to whether the stones cause gallbladder obstruction and bacterial infection. Larger stones are less likely to cause obstruction of the gallbladder, and patients do not feel any discomfort, and are only detected during ultrasound examination. Some patients have symptoms of chronic cholecystitis, such as epigastric fullness or vague pain after meals, epigastric discomfort and belching and other indigestion symptoms, which can be easily mistaken for gastric disease, and some patients may feel vague pain in the right upper abdomen and liver area. When the stone is embedded in the neck of the gallbladder or the cystic duct, a typical biliary colic attack occurs. It is characterized by a sudden onset of right upper abdominal colic with paroxysmal intensification and radiation to the right shoulder or chest and back, accompanied by nausea and vomiting. The onset of the disease is mostly related to diet, eating fatty foods, exertion and mental factors. In the early stage of the disease, there may be no chills and fever, but when the gallbladder is infected with septicemia, systemic symptoms such as fever, nausea and loss of appetite may appear. Gangrene and perforation of the gallbladder are serious complications of acute cholecystitis, with severe abdominal pain and rapid progression of the disease. Symptoms such as dehydration, shock and peritonitis also occur. In addition, some smaller stones can descend through the cystic duct into the common bile duct, which can cause acute purulent cholangitis, obstructive jaundice, acute or chronic pancreatitis and other corresponding clinical manifestations, which can be life-threatening when developed to this extent. So if you think you have “old stomach problems”, you must check for biliary system problems to avoid delays.