There are many serious immune system diseases, the common ones are systemic lupus erythematosus, idiopathic thrombocytopenic purpura, rheumatoid arthritis and so on. 1. Systemic lupus erythematosus (SLE): It is an autoimmune disease in which pathogenic autoantibodies and immune complexes are formed and mediate organ and tissue damage, and there are often manifestations of multi-system involvement, with the main pathological changes being inflammatory reactions and vascular abnormalities. The main pathological changes are inflammatory reactions and vascular abnormalities. The main symptoms are fever, rash and plasma membrane inflammation. It is not yet curable, and the complication rate is high, but long-term survival can be realized through active treatment. 2. Idiopathic thrombocytopenic purpura: It is an acquired autoimmune disease, which can be caused by genetic and infectious factors. The main symptoms can be manifested as skin bleeding, traumatic bleeding and so on. It is not yet curable and has a poor prognosis. 3. Rheumatoid arthritis: it is an autoimmune disease that can be caused by heredity, infection and other factors. The main symptoms can be manifested as joint swelling, pain and so on. Clinical cure is not yet possible, but if early detection, early diagnosis and early treatment, the prognosis is generally good; if the treatment is delayed, complications will occur in the later stage, and the disability rate will increase. In addition to the above diseases, clinically serious immune system diseases include systemic vasculitis, scleroderma, and autoimmune anemia. If you have any related immune system diseases, you should go to the hospital immediately, complete the relevant examinations, make a clear diagnosis, and actively cooperate with the doctor to standardize the treatment.