Patients with pancreatic cancer need chemotherapy. Systemic chemotherapy for pancreatic cancer can be used for postoperative adjuvant and neoadjuvant treatment of resected pancreatic cancer, as well as chemotherapy for advanced pancreatic cancer that cannot be resected or has metastatic lesions. Adjuvant chemotherapy for postoperative pancreatic cancer can reduce the chance of recurrence and metastasis in the future, thus improving the cure rate. For some patients with pancreatic cancer, it is difficult to remove the tumor surgically, and the complete removal of the tumor cannot be guaranteed, so preoperative chemotherapy, or neoadjuvant chemotherapy, can be administered in this case, and surgery can be considered after the tumor has shrunk. Patients with advanced pancreatic cancer with distant metastases can choose single chemotherapy or combined chemotherapy, while patients with locally advanced pancreatic cancer can choose chemotherapy alone or simultaneous radiotherapy depending on their general condition.