As an autoimmune disease, the pathogenesis of MG is immune-related, and immunosuppressants have been widely used in clinical practice with good results. Among them, glucocorticoids increase the release of ACh (acetylcholine) from the presynaptic membrane by inhibiting the synthesis of acetylcholine receptor antibodies and other skeletal muscle-related antibodies, and increase the number of acetylcholine receptors in the postsynaptic membrane to control MG symptoms. Other immunosuppressants such as cytotoxic drugs cyclosporine A, cyclophosphamide, azathioprine, FK506, etc. control the progression of MG by affecting the production of nucleic acids and inhibiting or killing immunologically active cells. Today we will talk about some basic knowledge of glucocorticoids. The indications for glucocorticoid application in MG are as follows: 1. Glucocorticoids are the first-line drugs for the treatment of MG and can bring about remission or significant improvement in 70-80% of patients; 2. They are usually effective in patients of all ages with moderate to severe MG, especially in adults over 40 years of age, regardless of whether they have undergone thymectomy; 3. Symptoms tend to improve within 6-8 weeks after application, with good results for both recent onset and chronic course, with exacerbation of symptoms occurring within 2-18 days and lasting up to 1 week after administration; 5.