Constipation is defined as difficulty or effort in defecation, poor bowel movement, reduced frequency of bowel movement, and low volume of dry stool. The first choice for constipation is to increase dietary fiber, drink more water, develop the habit of regular bowel movements, increase physical exercise, and avoid laxative abuse. Only when the above treatment is ineffective, drug treatment is chosen. Drug treatment mainly includes two categories of laxatives and motivational drugs. Laxatives: Laxatives play a laxative role by stimulating intestinal secretion and reducing absorption, increasing osmotic pressure and hydrostatic pressure in the intestinal lumen. They are generally divided into stimulant laxatives (such as rhubarb, senna, phenolphthalein, etc.), salt laxatives (such as magnesium sulfate), osmotic laxatives (such as mannitol, lactulose), swelling laxatives (such as bran, methylcellulose, polyethylene glycol, agar, etc.), and lubricating laxatives (such as paraffin, glycerin). Laxatives can be selected according to the severity of the patient’s constipation. For chronic constipation, bloating laxatives are appropriate, and stimulant laxatives are chosen only when necessary and should not be taken for a long time. Acute constipation can choose salt laxatives, stimulant laxatives and lubricating laxatives, but not for more than a week. Long-term chronic constipation, especially those who cause fecal impaction, can use the method of enema. Prokinetic drugs: commonly used prokinetic drugs are mosapride and itopride, whose mechanism of action is to stimulate the intestinal interosseous neurons, promote gastrointestinal smooth muscle peristalsis, promote the operation of the small and large intestine, effective for slow transmission constipation, can be used intermittently for a long time. Therefore, for patients with constipation, the first should be regulated by diet, exercise, lifestyle habits, etc., and then choose drug therapy when it is not effective, and the specific choice of which drug is also based on the specific situation of the patient.