In addition to improving menopause-related symptoms, a large number of evidence-based medical studies have confirmed that MHT can prevent chronic diseases of old age brought about by long-term estrogen deficiency. MHT has been the most controversial topic in the field of gynecological endocrinology for more than 70 years, with many twists and turns and many hardships, and there are still many controversies and misconceptions. In China, the problems faced by MHT are particularly serious due to the influence of traditional concepts and the lack of knowledge of gynecologic endocrinology among clinicians.