Hormone replacement therapy is one of the comprehensive health care measures for perimenopausal and postmenopausal women and should be discontinued once menopausal symptoms disappear. It is easy to relapse after discontinuation, but re-treatment is still effective. If middle-aged or elderly women have severe osteoporosis and cannot absorb calcium by supplementation alone, they can also continue to use hormone replacement therapy and review it regularly. At the same time, other measures should be taken in life, including reasonable diet, exercise, quitting smoking and limiting alcohol, combining work and rest, and using non-hormonal drugs, glucose- and lipid-lowering drugs, and osteoporosis treatment drugs. In general, the advantages of hormone replacement therapy outweigh the disadvantages, but it should be used under strict indications and under the guidance of a doctor. Hormone replacement therapy can benefit menopausal women in the following ways. 1. It has a moderating effect on menstrual disorders during the menopausal transition. More than 50% of postmenopausal women have hot flashes, night sweats, insomnia, and may experience anxiety, depression, and genitourinary tract atrophy, and hormone replacement therapy can eliminate hot flashes and genitourinary tract atrophy. It is reported that the efficiency rate is 90%~95% at 8 weeks of medication. 3. It can reduce the rapid loss of bone mass after menopause. Medical science has long found that estrogen deficiency is an important cause of osteoporosis during menopause. Estrogen replacement therapy can reduce osteoporotic fractures in patients and prevent further bone loss while stabilizing bone density. Bone loss is greatest in the first few years after menopause, at about 1 to 3 percent per year. This accelerated bone loss continues until age 75. For those who use hormone replacement therapy for more than 6 years, the risk of hip or wrist fracture can be reduced by 50%, and the incidence of vertebral deformity can be reduced by 90%. 4, can reduce the risk of ischemic cardiovascular disease and the rate of death. A large number of epidemiological studies show that the risk of ischemic cardiovascular disease in postmenopausal women using natural estrogen replacement therapy is reduced by 35% to 45%, and the risk of myocardial infarction is reduced by about 50%. Fifth, reduce the incidence of Alzheimer’s disease. The indications for hormone replacement therapy include: 1. Severe menopausal symptoms that affect the quality of life. 2. Premature ovarian failure due to surgery or disease. 3.Have high risk factors for osteoporosis. 4.Have high-risk factors for atherosclerosis and coronary heart disease. In the past, it was considered that hypertension, hyperlipidemia, diabetes, and a history of myocardial infarction were contraindications to estrogen administration. However, it is now believed that if other indications are clear, they can also be indications, but close monitoring is required. The main contraindications to hormone replacement therapy are estrogen-dependent tumors, unexplained vaginal bleeding, acute severe liver disease, porphyria, and the acute phase of embolic disease. In addition, hormone replacement therapy should be used with caution in patients with uterine fibroids, endometriosis, migraine, history of varicose veins or embolism, gallbladder disease, epilepsy, asthma, high risk factors for breast cancer (family history, benign breast disease, etc.), hypertension, hypertriglyceridemia, and diabetes mellitus. In terms of the choice of regimen, the physician’s decision is based on the patient’s complaints, the purpose of treatment (symptom relief, prevention of osteoporosis or coronary artery disease), past medical history, gynecological status (year of menopause, presence of a uterus, etc.), willingness to undergo cyclic vaginal bleeding, and the individual’s desire for which agent to use. However, regardless of the preparation and regimen, the initial dose should be reviewed at the hospital in 6~8 weeks as prescribed by the doctor, and once in 3~6 months thereafter, so that the doctor can keep abreast of the efficacy and side effects, and monitor blood pressure, weight, blood lipids, bone density, etc.