After treatment with recombinant human interferon vaginal suppositories for HPV infection, it takes as early as 3 months for the test result to turn negative, but it also takes 1-2 years for the test result to turn negative, and there are individual differences. Interferon is one of the medications used to treat cervical HPV infection, which can enhance the body’s immune system and thus inhibit the growth of the virus. The course of treatment with interferon is relatively long, and for those with mild symptoms, it may take 3 months for their condition to improve and for HPV to become negative, but for most patients, it takes 1-2 years for HPV to become negative. Even after using interferon vaginal suppositories, patients infected with HPV need to check their cervical TCT regularly, as long as the TCT is normal, there will not be much problem. If the patient’s cervical TCT is abnormal and cervical intraepithelial neoplasia has occurred, then timely colposcopic biopsy is needed, and the correct treatment will be carried out according to the pathological results. It is recommended that patients pay attention to rest, develop good habits, appropriate exercise, and dietary supplementation of vitamins in order to improve their physical condition and immunity.