I am a glioma. Those who don’t know me are fearless, those who know me are like seeing a snake. I am me, the dreaded glioma, the great killer of human life. = I am very cunning, although it hurts my pride to admit that I am cunning, but this really cannot be denied. I lurk quietly in the human brain, devouring the nerves, crowding the space of the brain, stimulating the cortex of the brain; when people notice it, they either have a headache, or have no strength in their arms and legs, or have difficulty speaking, or have a convulsion, and so on. This is when people go to the hospital and my natural enemy, the brain doctor, uses the human brain radar, the magnetic resonance imaging (MRI) scan, to detect me. That’s when I have nowhere to hide, so I hate brain doctors and MRIs. But sometimes I disguise myself as inflammatory in order to avoid being recognized, and MRI often thinks I am inflammatory, but some cunning doctors can still recognize me at a glance, and this time these guys will use spectral MRI (MRS) to identify me, quite effectively. It’s true that the devil is one foot taller than the other. Well, I won’t complain anymore. Let me tell you about my life. In fact, I was not a bad person originally. Although I can’t say where I came from, I know that I should be a normal cell transformation. Scientists found glioma stem cells in my body, and they were able to speculate that I was transformed from normal stem cells through genetic mutation, and later they found that normal mature cells can also become glioma stem cells through genetic mutation. In short, although the scientists found a lot of genes related to me and so on, they still couldn’t tell me exactly where I was from. This makes me very sad and feel like an orphan. Only when I destroy the human brain, I feel powerful. I was drunk on destroying the human brain. About my power, the brain surgeons used the phrase “a wildfire cannot be destroyed, but the wind blows again” to describe it. They tried to eradicate me, and they surgically struck me, cutting me out of the human brain in whole chunks, seemingly so clean that MRI could no longer detect me. But they got carried away too soon, and in a few months, or three or five years, I resurfaced and took over the same human brain I had occupied. The doctors could do almost nothing about it, sometimes they would hit me with surgery again, but many times they gave up. Of course, I also have untalented brothers, exceptionally kind-hearted and non-destructive, who were cut out once and never came back, and pathologists call my little brother a grade I glioma. The other three brothers are called grade II, III, and IV gliomas. grade IV gliomas are our big brothers, and they are particularly powerful and invincible. on average, humans do not live more than a year in the clutches of their big brothers. We sometimes have to admire our doctors for being so powerful. They racked their brains to eliminate us, in addition to surgical strikes, but also the use of radiation to kill us, with chemotherapy drugs to poison us, in an attempt to kill us in a hurry, although they did not achieve their dream, but did hit us hard, human beings can survive. But sometimes they also make mistakes, occasionally they use the gamma knife to shoot us, ha ha, the gamma knife does not work for us at all, but some doctors do not understand, some doctors pretend not to understand, it is best that they do not understand. As for chemotherapy drugs, we have a way to deal with that, we cleverly use the blood-brain barrier to weaken the toxicity of chemotherapy drugs. There is a natural barrier between the human brain and the blood, and most drugs have difficulty getting through this barrier to the human brain, which is a natural fortification for us. But there is one poison we are still a little afraid of, and that is temozolomide, the damn thing is more permeable to the blood-brain barrier. Well, with all that said, it’s time for me to take a break. In the battle with the brain surgeons, I am basically the final victor. As for those what Chinese medicine, what gene therapy doctors, at present I basically do not care, relatively speaking, I still respect my opponent, the regular brain surgeon.