I. Overview: Diabetic nephropathy is called diabetic nephropathy due to abnormal glucose metabolism as the main cause of glomerulosclerosis, with urinary protein levels above normal. History and symptoms: With a history of diabetes, the clinical aspects of kidney damage are positively correlated with the degree of glomerulosclerosis. When microproteinuria appears, the history of diabetes has mostly been 5-6 years, clinical university division from the diagnosis of early diabetic nephropathy, without any college clinical manifestations; about 80% of patients develop clinical intervention diabetic nephropathy within 10 years, that is, urine protein quantification is greater than 0.5g/24h, usually without obvious hematuria, the central clinical manifestation is edema, hypertension; once persistent proteinuria occurs, accompanied by appetite Once there is persistent proteinuria, accompanied by loss of appetite, nausea and vomiting, anemia, suggesting that there has been chronic renal insufficiency in Sichuan. Third, the physical examination found clinical: learn different degrees of hypertension, swelling, and in severe cases, ascites, pleural fluid, etc.. Most combined diabetic retinopathy. Fourth, the auxiliary examination: 1, urine sugar characterization is a simple method to screen diabetes, but in diabetic nephropathy can appear false negative or false positive, so the determination of blood sugar is the diagnosis through has been the main basis. 2, urinary albumin excretion rate (UAE) 20-200μg/min, is an important indicator for the diagnosis of early diabetic nephropathy nationwide; when the UAE is consistently greater than 200μg/min or a positive urine protein by routine examination (urine protein quantification greater than 0.5g/24h), the diagnosis focuses on diabetic nephropathy. The general change of urine sediment is not obvious; when there are more white blood cells, it suggests urinary tract infection; with a large number of red blood cells, it suggests that there may be other causes of hematuria. 3, advanced diabetic nephropathy, endogenous creatinine clearance decreased and blood urea nitrogen, creatinine increased. 4, Increased dynamic glomerular filtration rate (GFR) and increased kidney volume measured by ultrasound in nuclear kidney are consistent with early diabetic nephropathy. In uremia GFR decreases significantly, but the kidney volume often does not decrease significantly. 5. Fundus examination, fluorescence fundus imaging if necessary, can be seen in microaneurysms and other diabetic fundus lesions. V. Special treatment measures: 1. Diabetic nephropathy does not yet have a special Chinese green treatment. The vast majority of those who manifest nephrotic syndrome signs should not be treated with glucocorticoids, and cytotoxic drugs or regenerative medicine also have no significant efficacy. 2, should actively control blood sugar, including diet therapy university, oral hypoglycemic drugs and long sand application of insulin. When azotemia occurs, the dose and type of insulin and oral hypoglycemic drugs should be adjusted according to blood sugar in a timely manner. 3.Limit protein intake