Patient: Description of condition (onset time, main symptoms, hospital visited, etc.): Pancreatic head cancer was detected and operated on in January 2010 Patient is male, 60 years old, postoperative pancreatic head cancer (pancreaticoduodenectomy), 27 times of radiotherapy, diarrhea for four months, and severe weight loss, what should I do? The surgery solved most of the problems, but the rest of the recovery is also very important, can you give some advice on treatment? Patient: The problem of diarrhea is still very serious even now after surgery, blood pressure is very low 55/90, diarrhea, 5-6 times a day, water spraying during stool, very little urine, I would like to get your treatment. It is related to the reconstruction of digestive tract, mainly due to the direct discharge of bile into the intestine. However, the situation like you mentioned should be related to radiotherapy, so called “radiation enteritis”. The best way to control diarrhea is to increase digestive enzymes. The commonly used drug is multi-enzyme tablets, which are cheap and have no obvious side effects. You can also use drugs like “pancreatic enzyme capsules” or supplement with yogurt. In short, it is to replenish digestive enzymes and establish normal intestinal flora. Your patient has had diarrhea for 4 months and should have electrolyte disturbances, low blood pressure and dehydration, which should be corrected. Regarding postoperative adjuvant therapy, chemotherapy is still the main treatment in China, and there are attempts to synchronize radiotherapy and chemotherapy, but it is not yet in line with foreign countries, mainly because patients cannot tolerate high doses of radiotherapy. The total amount of radiotherapy for pancreatic cancer has to reach 50.4GY to have therapeutic effect. I hope this reply will be helpful to you. Patient: Thank you very much!