The factors that contribute to the development of primary osteoporosis vary depending on the type of osteoporosis. Postmenopausal osteoporosis is mainly caused by a dramatic decrease in estrogen levels in women, and senile osteoporosis is mainly due to a significant decrease in osteogenic capacity and a loss of coupling between osteoblasts and osteoclasts due to aging. Prevalent factors for osteoporosis include genetic factors (osteoporosis or fracture in relatives), inadequate calcium intake, lack of proper exercise and sports, insufficient sunlight, premature menopause in women, long-term use of steroid drugs, smoking or excessive alcohol consumption, low body weight, chronic diseases of other organs such as liver and kidney diseases, gastrointestinal malabsorption, hyperthyroidism, etc. The clinical manifestations of osteoporosis mainly include 1. pain: the most common site is low back pain, other areas include joint pain in the limbs, heel pain and radiating pain, numbness and tingling sensation in some limbs, etc. 2, height shortening or hunchback: usually the more severe the osteoporosis, the lower the position of the apex of the hunchback, and the more severe the hunchback. 3. Fracture: Due to the increased brittleness of bone in osteoporosis, a slight external force can lead to fracture, i.e. osteoporotic fracture. Common sites include the thoracic and lumbar vertebrae, the distal radius and the proximal femur. Osteoporotic fractures seriously endanger the health of middle-aged and elderly people and even endanger their lives. Moreover, the cost of prevention and treatment and the dependence of patients on family members bring a heavy burden to society.