In 1903 Riggs and Melton divided osteoporosis into 2 disease types: postmenopausal (type I) osteoporosis and senile (type II) osteoporosis. The main cause of the former is estrogen deficiency, while the main etiology of the latter is considered to be due to abnormalities in calcium and Vit D metabolism with increasing age. The RDA (recommended daily allowance) of calcium for adults in China and the United States is 800mg per day, while we can find that some of the foods with high calcium content published by the Chinese Academy of Preventive Medicine and the Institute of Food Hygiene are some side dishes, so the dietary structure of our residents can only ensure a daily intake of dietary calcium of 400mg, and what is worse is that after middle age, the intestinal absorption rate of calcium decreases, and the utilization and storage of calcium is poor. The use and storage of calcium is poor, prone to the negative balance of calcium metabolism. Therefore, it is more important to supply enough calcium to maintain the normal metabolism of calcium in middle and old age. In addition to calcium supplementation, special attention should be paid to VitD supplementation because VitD is the precursor of the renal calcium-activating hormone, 1,25-dihydroxycholecalciferol [1,25-(OH)2D3], which is formed under the successive action of hepatic 25-hydroxylase and renal 1-hydroxylase and can promote intestinal calcium absorption; promote bone resorption and bone formation metabolism; and regulate bone metabolism. It can promote intestinal calcium absorption; promote bone resorption and bone formation metabolism; promote renal tubular calcium reabsorption; reduce PTH secretion; and regulate cytokine secretion of immune cells. Thus, it can reduce the incidence of vertebral fractures due to osteoporosis (16-18), but excessive granting of VitD can cause hypercalcemia, hypercalciuria, and renal dysfunction, in addition to hyperresorption of bone and VitD toxicity. Usually, VitD supplementation of 1000u daily is sufficient, and more outdoor activities to receive sunlight exposure. There are many calcium supplements on the market today, so when choosing one, you should consider calcium supplements with high elemental calcium content, such as calcium carbonate, which has a high elemental calcium content of 40%, followed by calcium phosphate at 23-38%, calcium chloride at 27%, calcium citrate at 21%, and calcium citrate at 21%. VitD is usually available in the form of cod liver oil, VitD3, Mungerwang (1-OH-D3), and rocuronium [1,25-(OH)2D3], and the literature reports that active VitD is best given to older patients with poor liver and kidney function and has better clinical results (19). good (19), but the effect of VitD on bone mineral density, like other drugs for osteoporosis, is difficult to show changes in the short term or even a slow decline, which may be related to the VitD allele (VDR) (20).