Chronic hepatitis B patients with liver fibrosis treatment need to take antiviral drugs, anti-inflammatory and hepatoprotective drugs, anti-hepatic fibrosis drugs and so on. Hepatitis B virus infection can cause diffuse damage to hepatocytes, such as long-term action, repeated episodes led to extensive collagen fiber proliferation in the liver, gradually developed to the presence of excessive collagen deposition in the liver. Another part of patients with liver fibrosis, but also cause portal hypertension and esophageal varices. Therefore, when liver fibrosis occurs in hepatitis B patients, not only do they need to take antifibrotic drugs such as Anluohua Fibroblast Pill and Hepatoflora, but they also need to undergo antiviral therapy and anti-inflammatory and liver-protecting treatments. Antiviral treatment includes lamivudine, entecavir, tenofovir, or pegylated interferon-alpha, and anti-inflammatory liver-protecting treatment can use glutathione, bicyclic alcohol, thiopronin, ursodeoxycholic acid and other drugs. Chronic hepatitis fibrosis patients treatment, the specific use of drugs need to be judged by a professional doctor to choose, patients are prohibited from taking their own medication.