Primary liver cancer is a common malignant tumor. Because of insidious onset, no or insignificant symptoms in early stage and rapid progress, most patients have reached locally advanced stage or distant metastasis when diagnosed, which makes treatment difficult and prognosis very poor. If liver cancer can be detected early and through active and standardized treatment, the survival rate of liver cancer can be greatly improved, and most of the early stage liver cancer can be cured. Therefore, early detection of liver cancer is very important. 1. Monitoring and screening of high-risk groups. The etiological factors of liver cancer in China mainly include hepatitis virus infection, food aflatoxin contamination, long-term alcohol abuse and blue-green algae toxin contamination of rural drinking water, other liver metabolic diseases, autoimmune diseases and cryptogenic liver disease or cryptogenic cirrhosis. About 90% of liver cancers in China are mainly caused by chronic hepatitis B and liver cirrhosis. Since early diagnosis of liver cancer is crucial for effective treatment and long-term survival, early screening and early surveillance of liver cancer are highly emphasized. Routine surveillance screening indicators mainly include serum fetoprotein and liver ultrasonography. For men ≥ 40 years of age or women ≥ 50 years of age with high pressure bias or hepatitis C virus infection, alcoholism, combined diabetes mellitus and family history of hepatocellular carcinoma, screening is generally performed at 6-month intervals. 90% of liver cancer can be detected early through serum fetoprotein and liver ultrasonography. 2. Surveillance screening for healthy people. We know that there are still some liver cancer patients without history of hepatitis or cirrhosis, so health checkups should also be conducted for healthy people, and annual liver ultrasound and fetoprotein examination is recommended. Can early stage liver cancer be self-detected? Subclinical pre-stage (early stage) liver cancer refers to the period from the beginning of the lesion to the diagnosis of subclinical liver cancer, when the patient has no clinical symptoms and signs and is difficult to detect clinically, usually about 10 months. In the subclinical stage (early stage) of hepatocellular carcinoma, the tumor is about 3-5 cm, most patients still have no typical symptoms, and the diagnosis is still difficult, mostly detected by serum AFP census for about 8 months on average, during which a few patients can have symptoms related to chronic underlying liver disease such as epigastric stuffiness, abdominal pain, weakness and loss of appetite. Therefore, those who have high-risk factors and experience the above conditions should be alerted to the possibility of liver cancer. Once typical symptoms appear, such as pain in liver area, loss of appetite, wasting, jaundice and fever, etc., they are usually in the middle or late stage of liver cancer, at which time, the disease develops rapidly and medical treatment is very limited, and the survival period is usually about 3-6 months. Therefore, for the health of you and your family, it is especially important to have regular medical checkups.