Some people in life unfortunately suffer from cranial defects for one reason or another. The skull is an important protective barrier for the brain, and a skull defect is bound to have a great impact, which should be remedied by having a skull repair surgery. The choice of material for skull repair surgery will restrict the results after the surgery, so patients should be careful about this issue. From ancient times to the present, skull repair surgery has become more and more mature, and the materials used are also developing in the direction of more safety and progress. Currently, many hospitals are using titanium mesh material for skull repair surgery. Although titanium mesh is more advanced than the early bone cement, artificial bone and plexiglass materials, there are many unavoidable problems. Exposure of titanium mesh is one of the most common ones, and many people in clinical practice have experienced exposure after using titanium mesh for skull repair surgery. What will happen if the exposed titanium mesh is not removed? Exposed titanium mesh is a serious problem, and if it is not removed in time, the exposed part is prone to infection, leading to local inflammation, and the brain tissue is also prone to external aggression, which is a very dangerous situation. Therefore, in case of exposed titanium mesh, patients must go to the neurosurgery department of traumatic cerebrovascular disease for another examination, so that specialists can remove the exposed titanium mesh material and carry out repair work in time. The use of titanium mesh has many limitations, and a safer material is needed instead. At this time, polyether ether ketone material (peek material) appeared, after a lot of clinical practice, peek material is currently the most ideal material to do skull repair, its performance in all aspects are quite excellent, the patient will not have any discomfort after surgery, has a very high evaluation. The appearance of peek material, successfully avoiding the various defects of titanium mesh material, is a major medical breakthrough. peek material’s various physical and chemical properties are comparable to that of autologous cranial bone, and it also has the function of three-dimensional reconstruction production, which can be shaped according to different patients’ conditions, and the post-operative effect is quite perfect.