Dry eye is a chronic disease with a complex pathology. The pathological changes of the ocular surface are extensive, and the inflammatory response of immunity, apoptosis, reduction of sex hormone levels and the influence of the external environment are the main factors in the development of dry eye. We believe that the main factors of dry eye syndrome are: 1. Video terminal syndrome: Due to modern life, young people’s work and entertainment and television, computer contact more and more, prolonged exposure to fluorescent screens, blinking times from 20 to 25 times per minute reduced to 5 to lO times per minute, transient habits change, lack of timely blinking or let the eyes rest, tear secretion reduced, eye exposure to the air, excessive evaporation of moisture. In addition, the electromagnetic waves and harsh colors of the screen will stimulate the eyes, resulting in dry eyes, itchy eyes, visual fatigue and other symptoms; 2, wearing contact lenses: long-term wearing of corneal contact lenses may lead to thinning of the lipid layer of the tear film, causing a decline in tear secretion; 3, eye surgery and the use of eye drops: eye surgery and post-operative hormonal eye drops will damage the tear film, which can 4, age: because the tear gland atrophy aging, tear secretion gradually reduced, so the elderly dry eye patients accounted for a considerable part, but in recent years, the prevalence of dry eye disease to the lower age development, and young people with bad eye habits and excessive use of eyes closely related to; 5, gender: the proportion of women in the study group accounted for a high, II and III group of amenorrhea dry eye patients occupy a significant part, according to research estrogen can promote the secretion of the lacrimal gland, regulate the function of the lid gland and the secretion of lipids in tears, and estrogen receptor gene polymorphisms are associated with the presence of postmenopausal dry eye. Diabetes, immune disorders, vitamin A deficiency, lid gland dysfunction, and other physiological causes such as inadequate or poor sleep quality and mental stress can cause a decrease in tear quality. The evaporation of tears increases due to dry climate, atmospheric pollution, low humidity in the room, etc. After more than ten years of research, it was found that immune inflammatory factors play a very important role in the pathogenesis of dry eye, so anti-immune inflammatory response ophthalmic drugs have been used to achieve clinical results in the treatment of dry eye, and such drugs include corticosteroid ophthalmic solutions, cyclosporine eye drops, and non-steroidal anti-inflammatory ophthalmic solutions (such as pralophine). The ocular surface toxicity caused by the preservatives contained in artificial tears is becoming a concern in the treatment of dry eye. Diabetes mellitus, immune disorders, vitamin A deficiency, lid gland dysfunction, etc.