Pacemaker therapy has been carried out in China for 15 years since 1998, but many people are still not very familiar with this therapy. A patient named Miracle, now 42 years old, suffered from Parkinson’s disease since he was 27 years old, manifesting as stiffness, slow movement, delayed walking and tremor. In the first 3 years, the medication was effective and the symptoms were well controlled. Miracle symptoms gradually worsened, and after 5 years the drug effect was significantly reduced, the duration of drug maintenance was significantly shortened, and involuntary dance-like movements of the limbs (heterokinesia) appeared when the drug took effect, and this condition became more and more powerful. Ten years after the onset of the disease, Miracle’s condition became more and more serious, and he could not go out alone and had to be accompanied by his family members when he went out on the street. Despite this, Miracle joined the “Guangzhou Parkinson’s Patients Club” in 2004 and has been participating in the activities of the club since then, encouraging the patients to continue to participate in various social activities and work, and giving support and care to many Parkinson’s patients. In May 2013, Miracle participated in the “Clinical Trial of Domestic Suzhou Jing Yu Brain Pacemaker Implantation” as a volunteer at the First Hospital of Guangzhou Medical University and had a free “brain pacemaker” implantation. After the surgery, Miracle’s medication dosage was significantly reduced, and his anisometropia was basically relieved, and he was able to move around freely. Six months after the surgery, he was able to take care of himself completely, and he could go out alone, and visited his friends and family in Guangxi alone, and traveled to Macau many times. Another young patient, now 20 years old, from Meizhou, started to suffer from “torsional spasm” at the age of 9, manifested by abnormal movements of the right hand twisting, the fingers could not be straightened, gradually spreading to the left hand. 11 years old developed into the cervical, thoracic and lumbar vertebrae bent to the left side and twisted. 12 years old developed into both lower limbs and head twisted to one side, unable to walk independently, obviously affecting the life and life. At the age of 13 (September 2007), due to the family’s financial difficulties, the family recruited nearly 100,000 Yuan in donations from the society and spent 200,000 Yuan in total for the “bilateral brain pacemaker surgery” at the First Hospital of Guangzhou Medical University. Pacemaker surgery” was performed at the First Hospital of Guangzhou Medical University. Three weeks after the operation, the patient’s torsion was gradually reduced, and three months after the operation, the patient’s limbs and trunk torsion were obviously relieved, and the symptoms were significantly improved, and he could basically take care of himself. The patient has been treated without oral medication after the operation. After 7 years of post-operative follow-up without complications and without medication, his height grew from 1.3 meters to 1.7 meters, and he finished his junior high school education and has been working for two years. Both of these patients have one thing in common in their treatment process – a brain pacemaker. Let’s take a look at what a pacemaker is. The brain pacemaker, also known as deep brain stimulation (DBS), is a major milestone in the treatment of Parkinson’s disease. By implanting electrodes in specific nuclei in the brain and releasing high-frequency electrical stimulation, it inhibits the electrical impulses of these neurons that are over-excited due to a decrease in dopaminergic neurons, diminishing their over-excited state and reducing Parkinson’s disease symptoms. The therapy relieves the three main symptoms of Parkinson’s disease: tremor, rigidity and bradykinesia, and also improves difficulty in starting and turning over, and has significant efficacy in motor complications such as heterokinesia and on-off phenomenon. The pacemaker is a compact microelectronic device consisting of a pulse generator, an electrode and an extension lead, all implanted in the body with only a few small surgical scars on the skin surface. The implanted components do not interfere with the patient’s daily life. The doctor can regulate the parameters needed to improve the patient’s condition by pointing a remote control at the microcomputer stimulator buried under the patient’s skin, so that the “wooden man” who was suffering from Parkinson’s disease and couldn’t walk around can walk around in a blink of an eye; the patient whose limbs kept trembling can become quiet when the regulator is pressed. Moreover, the stimulation effect of the “brain pacemaker” is reversible, and its effect stops immediately when the stimulation power is turned off. Secondly, the pacemaker does not cause permanent damage to brain tissue and does not interfere with other treatments in the future. In addition, pacemaker therapy can also treat idiopathic tremor, generalized dystonia (torsional spasm), obsessive-compulsive disorder, intractable epilepsy, major depression, drug addiction, and other neuropsychological disorders. Currently, there are three major brands of brain pacemaker products in China, namely Medtronic from the United States, Pinch from Beijing Tsinghua, and Jing Yu from Suzhou. Medtronic has a complete range of products listed in China; most of Pinchi’s products are currently listed in China; some of Jing Yu’s products are in clinical trials and ready to be listed. Through clinical observation, domestic pacemakers are no less effective than American brands, but of course, domestic pacemakers are cheaper than imported ones, which means that patients can have more choices when they undergo pacemaker therapy, and choose the therapy that suits them according to their affordability. The First Hospital of Guangzhou Medical University has been carrying out brain pacemaker therapy since 2004. The equipment and technology are quite mature, and it is a DBS team consisting of neurology, neurosurgery, imaging, surgical anesthesia, and psychology to manage patients in all aspects, and has successfully operated on hundreds of patients to relieve their pain.