When it comes to osteoporosis, many friends will almost always say these words lightly: “Oh, it’s just a disease of old age, we all have it when we get older”; “Just take more calcium tablets”; “I’m still young, I won’t have this I’m still young, I won’t have this disease.” …… Many patients with a clear diagnosis of osteoporosis either agree or are confused by these opinions. Our body’s vital skeletal tissue is often overlooked because of its inherent low metabolic rate and is often thought of as a hard, non-living tissue like steel and concrete. This concept can lead us astray in our understanding of bones. The bones are in a dynamic balance with the skin, hair, nails and other human tissues, which have the ability to metabolize and build new tissues. Osteoporosis is a disease in which this balance is disrupted by a state of disease, resulting in problems with bone tissue. According to the latest National Institutes of Health (NIH) definition, osteoporosis is a bone disease in which the risk of fracture is increased due to a decrease in bone strength; bone strength is mainly reflected by bone density and bone mass. However, it is not enough to have such inorganic minerals, but bone tissue also needs organic proteins called “collagen” to form the framework structure so that minerals can be attached to such organic protein framework in an orderly manner. In order for minerals to be attached to this organic protein framework in a step-by-step manner, the bones are formed with a certain degree of hardness and toughness. This sophisticated combination of two types of cells in our body, osteoblasts and osteoclasts, works together. The familiar and misunderstood osteoporosis is the result of a problem with these two types of cells, either the osteoclasts are overactive and dismantle too much waste tissue, or the osteoblasts are lazy and create too little new tissue, resulting in osteoporosis. For the treatment of osteoporosis, many people think that it is enough to supplement with enough mineral raw materials, that is, calcium and phosphorus and many other trace elements. But this happens to be far from enough! It is like a factory to produce quality products, only sufficient raw materials is not enough, the key is to rely on skilled workers and well-designed assembly line for the raw materials to be processed adequately. In bones, such skilled workers are used to restore osteoclasts and osteoblasts that are not working properly by using special therapeutic drugs, while the assembly line is used to monitor the osteoclasts and osteoblasts properly by monitoring the bone conversion index. According to a study in the United States, giving calcium supplements alone to patients with osteoporosis did not result in improved bone density or reduced fracture risk. This is ample evidence that the method we originally thought of as simply supplying raw materials is not a reasonable and effective approach. Many people think that osteoporosis is a disease of the elderly, and this idea is completely wrong. Osteoporosis can occur at any time in our lives, it is just that the incidence of this disease increases as we age. In fact, osteoporosis is often overlooked in clinical practice, such as in rheumatic diseases like lupus erythematosus and rheumatoid arthritis, in hormone suppression therapy after breast cancer and prostate cancer, in thyroid hormone suppression after thyroid cancer surgery, and in nutritional supplementation during pregnancy and lactation, etc., etc. …… is an endless list, and we often focus on the treatment of these primary diseases and ignore the osteoporosis that does not talk about it. However, clinical data show that treating these primary diseases along with the coexisting osteoporosis can lead to a “1+1>2” treatment effect. For example, treatment of breast cancer patients with anti-osteoporosis drugs such as zoledronic acid, a bisphosphonate, significantly improves the postoperative life of patients and significantly reduces the rate of bone metastases and prolongs the survival time of patients with breast cancer. The same findings have been found in studies of rheumatoid arthritis, prostate cancer, and other diseases. This reminds us that although bones do not speak, our attention and focus will inevitably bring us a quiet return. In modern society, due to the change of lifestyle, the increase of high-salt and high-fat diet, the decrease of physical activity, and the consumption of sweet carbonated beverages have put a lot of pressure on our bone health, thus osteoporosis has quietly targeted the young population, which needs our attention and attention. Avoid unhealthy lifestyles, rational application of anti-osteoporosis drugs (not only calcium tablets!) And regular monitoring of bone density and bone metabolism indicators, this is the prevention and treatment of osteoporosis “Three Musketeers”, one can not be missing.