Due to the infiltrative growth characteristics and anatomical location of glioma, surgery is difficult to remove completely, and a combination of surgery, radiotherapy and chemotherapy is required. Gliomas are classified into four grades according to the degree of malignancy: grade I can usually be cured by surgery alone, and some require combined radiotherapy; grade II can be removed surgically with or without combined radiotherapy or chemotherapy, and some patients can be treated directly with radiotherapy after clear pathology; grades III and IV are malignant gliomas, which require combined treatment with surgery, radiotherapy and chemotherapy. The treatment of glioma emphasizes personalized and comprehensive treatment, and there are 2 keys, surgical resection is one of them, and the other key is to take continuous and effective treatment after surgery. Surgery is the main treatment for glioma. For tumors located in or near functional areas of the cerebral cortex, the principle of surgery is to maximize resection of the tumor while maximizing preservation of the patient’s neurological function to ensure the quality of survival. Currently, surgery combined with advanced techniques such as microfluorimetry, functional MRI, electrophysiological monitoring, and intraoperative wake-up anesthesia can increase the resection rate and the preservation of brain function. Radiotherapy is one of the important treatment methods for glioma treatment, which can kill the remaining tumor cells after surgery. Radiotherapy is usually administered within 2-4 weeks after surgery. X-blade and gamma knife treatment is not recommended for primary glioma. It is divided into external radiotherapy (i.e., what the people call baking electricity) and internal radiotherapy. External radiotherapy includes conformal 3D intensity modulation, X-knife, gamma knife, etc. It can only treat 1 course of treatment for life, and has greater complications such as radioactive brain damage, decreased hematopoietic function or nausea and vomiting, hair loss and scalp necrosis. Internal radiotherapy refers to isotope interstitial radiotherapy, including stereotactic particle implantation and balloon method internal radiotherapy device method, the former requires surgery and is restricted, the latter only uses syringe puncture subscalp injection pump regularly replaced with new isotopes such as 32P and 125I, etc. The balloon method of internal radiotherapy device is easy to operate, low cost, and can be used for multiple courses of treatment without obvious side effects, which is the most scientific and effective radiotherapy measure and the treatment method invented by Yishui Central Hospital. Chemotherapy is an indispensable part of the comprehensive treatment of malignant glioma. Chemotherapy can further kill residual tumor cells and reduce recurrence. Chemotherapy can be given simultaneously with radiotherapy, or after surgery or radiotherapy, or as the first choice of treatment for some recurrent gliomas. The use of oral temozolomide combined with balloon method isotope internal radiotherapy can effectively prevent the side effects of external radiotherapy such as nausea and vomiting as well as radioactive brain damage and decreased hematopoietic function, thus maximizing the combined chemotherapy and improving the treatment effect. Hyperbaric oxygen therapy can improve the effect of radiotherapy, and also has a therapeutic effect on brain injury such as surgery or radiation brain injury.