Chronic kidney disease stage IV is usually more serious, continue to progress and deteriorate can become uremic syndrome, how long it takes is not yet clearly determined. Chronic kidney disease stage IV is a serious decline in kidney function, glomerular filtration rate of 29-15ml/min, the patient’s condition is more serious, such as the continued progress will become uremic syndrome, the need for hemodialysis treatment. There is no clear clinical conclusion on the time of progression of chronic kidney disease stage IV to uremia, which mainly depends on the degree of control of the patient’s condition. If a patient has a co-infection or poorly controlled blood pressure, he or she may suddenly progress to uremic syndrome within a month or a few days. If the patient has no infection and good blood pressure control, the time to turn to uremic syndrome may be relatively longer. If Chinese medicine treatment is used, the progression can often be delayed. For patients with chronic kidney disease stage IV, daily rest should be paid attention to avoid strain and infection, strict control of blood pressure, reasonable application of antihypertensive drugs and avoid application of nephrotoxic drugs, etc., which can slow down the progression of the disease.