Fruit acids have gained positive results as chemotherapy in acne treatment. Fruit acids are widely found in fruits, sugar cane, and yogurt. They have a simple molecular structure, small molecular weight, are non-toxic and odorless, and have strong permeability and safe action. The mechanism of action is to reduce the adhesion of keratinocytes by interfering with the binding force on the cell surface, accelerate the shedding and renewal of epidermal cells, regulate the secretion of sebaceous glands, and stimulate the synthesis of dermal collagen, increase mucopolysaccharide and promote tissue repair. Treatment protocol: Application of glycolic acid (also known as glycolic acid, derived from sugar cane) at 20%, 35%, 50%, and 70% concentrations to treat acne, with increasing concentrations or dwell time depending on the patient’s tolerance level. Treatment is given once every 2-4 weeks, with 4 sessions being a course of treatment. It is effective for both inflammatory and non-inflammatory lesions. After fruit acid treatment, localized light erythema, white cream, swelling, stinging and burning sensation may appear, all of which can be recovered within 3-5 d. If post-inflammatory pigmentation occurs, it will take 3-6 months to recover. Pay attention to sun protection and moisturizing during the treatment interval, and can be combined with the application of medical skin care products.