There is no authoritative literature on the best treatment for hemangiomas inside the corners of the mouth in adults, which are usually treated minimally invasively as follows. Under color Doppler ultrasound guidance, the patient is injected with pingyangmycin and embolized with a gelatin sponge at the beginning of the patient’s diseased tertiary artery. Pingyangmycin inhibits the vascular endothelium, destroys the blood sinus endothelium and vascular endothelial cells, and narrows the lumen of the vessel, ultimately leading to vascular atresia. Minimally invasive treatment causes less trauma, has a lower complication rate, has less impact on oral function, and facilitates postoperative recovery and care. For some small hemangiomas or the effect of drug injection is not obvious, surgical removal can also be considered. It is recommended to visit a regular medical institution in time to receive professional treatment with the help of a doctor.