Bone is an important organ of the human body and its strength depends on the bone mineral and bone matrix content (together called bone content). Human bone mineral is gradually increasing until the age of 35, reaching a peak around the age of 35, and a stable period from 35 to 45, after which it starts to decline, with an average loss rate of more than 1% per year. Especially after menopause, due to the rapid decline of estrogen levels in women, bone mineral loss is rapid, and compared to men, women’s bone mineral loss rate is almost three times that of men, making them more susceptible to osteoporosis. Osteoporosis is a group of bone diseases caused by various reasons. It is a metabolic bone lesion characterized by a decrease in the amount of bone tissue per unit volume, with normal calcification of bone tissue and a normal ratio of calcium salts to matrix. In most cases of osteoporosis, the decrease in bone tissue is mainly due to increased bone resorption. The onset of osteoporosis is slow and individual is fast, characterized by skeletal pain and easy fracture, and biochemical tests are basically normal. The pathological anatomy shows a thin bone cortex and sparse atrophy of bone trabeculae with no thick bone layer. With the aging of the population, the incidence of osteoporosis is on the rise. According to relevant data, in western countries such as the United States, the United Kingdom, Italy and Japan, the prevalence of osteoporosis in women aged 50-69 years is 20%-28%, in women aged 70-79 years, the prevalence of osteoporosis reaches 40%, and in women aged 80 years and above, the prevalence is as high as 80%. Therefore, prevention of osteoporosis is very important for middle-aged and elderly people. At present, the following four kinds of drugs are available for the treatment of osteoporosis: 1.Bone peptide tablet, which is used to treat rheumatoid rheumatism, is the only oral bone peptide preparation, can directly reach the site of osteoporosis, good targeting, contains a variety of bone growth factors. 2.Alendronate: the trade name Fosamax inhibits the role of osteoclasts and has the effect of prevention and treatment of osteoporosis at the same time. 3.Calcitonin: absorbed by subcutaneous, intramuscular injection or nostril, effective for women with osteoporosis who have stopped menstruation for more than five years. Side effects include loss of appetite, flushing, rash, nausea and dizziness. However, as soon as the medication is stopped, the rate of bone loss will begin to accelerate, so long-term treatment is necessary. 4.Calcium and vitamin D: The combination is more effective. 5.Hormone supplementation therapy: Estrogen plus progestin can prevent and treat osteoporosis. If there is no uterus, progestin is not needed. Prevention Osteoporosis brings great inconvenience and pain to patients’ lives, and the treatment is very slow, and once the fracture is life-threatening, therefore, special emphasis should be placed on the implementation of the three levels of prevention. 1, primary prevention: should start from children and adolescents, such as pay attention to reasonable dietary nutrition, more food containing high Ca, P, such as fish, shrimp, shrimp skin, kelp, milk (250ml contains Ca300mg), dairy products, bone broth, eggs, beans, refined grains, sesame seeds, melon seeds, green leafy vegetables, etc.. Try to get rid of “risk factors”, adhere to a scientific lifestyle, such as adhere to physical exercise, more sunbathing, do not smoke, do not drink alcohol, less coffee, strong tea and carbonated beverages, less sugar and salt, animal protein should not be too much, late marriage, less childbearing, breastfeeding period should not be too long, as far as possible to preserve the calcium in the body, enrich the calcium pool, the bone The best measure to prevent osteoporosis in the later stages of life is to increase the peak value of calcium to the maximum. Strengthen the basic research of osteoporosis, and focus on the follow-up and early prevention for the high-risk groups with genetic predisposition. 2.Secondary prevention: bone loss accelerates in middle age, especially after menopause in women. Bone density examination should be conducted annually during this period, and prevention and control measures should be taken early for people with rapid bone loss. In recent years, most scholars in Europe and the United States advocate starting long-term estrogen replacement therapy within 3 years after menopause, while insisting on long-term preventive calcium supplementation or using solid bone peptide preparation bone peptide tablets for prevention, in order to safely and effectively prevent osteoporosis. In Japan, it is mostly advocated to prevent osteoporosis with active Vit D (rocalciferol) and calcium, and to pay attention to the active treatment of diseases related to osteoporosis, such as diabetes, rheumatoid arthritis, steatorrhea, chronic nephritis, hyperparathyroidism/hyperthyroidism, bone metastatic cancer, chronic hepatitis, liver cirrhosis, etc. 3.Tertiary prevention: Patients with degenerative osteoporosis should be actively treated with drugs to inhibit bone resorption (estrogen, CT, Ca), promote bone formation (active Vit D), bone peptide tablets, etc. Measures to prevent falls, bumps, trips and upsets should also be strengthened. For middle-aged and elderly patients with fractures, they should be actively operated, implement strong internal fixation, early activity, physical therapy, physiotherapy psychological, nutrition, calcium supplementation, pain relief, promote bone growth, curb bone loss, improve immune function and overall quality and other comprehensive treatment. Degenerative osteoporosis is the basic law of bone development, growth and aging, but is subject to hormonal regulation (mainly PTH bone breaking: estrogen, CT osteogenesis; Vit D3 two-way regulation), nutritional status, physical factors (sunlight, weight), immune status (systemic physique, disease), genetics, lifestyle (smoking, alcohol, coffee, diet, exercise, mental and emotional), economic and cultural Degenerative osteoporosis can be delayed and prevented if self-care awareness is strengthened early, self-care level is improved, and scientific intervention is actively carried out.