There is no such thing as “the most difficult eye disease to treat”, but there are some eye diseases that are more difficult to treat, such as ocular malignant tumors, fungal infections or optic nerve atrophy. Although the current clinical treatment of drugs and surgery and other treatment modalities are developing rapidly, there are also many ophthalmic diseases that are very difficult to treat, such as malignant melanoma of the eyelid or retinoblastoma caused by genetic factors, etc., which, if not detected in a timely manner and without timely and effective treatment, not only pose a great threat to the patient’s vision, but also endanger the patient’s life in the most serious cases. Since there are no anti-infective drugs that work well against corneal or intraocular fungal infections, and the existing antifungal drugs can produce large ocular and systemic adverse effects, there is still nothing that can be done to treat fungal infections that have already progressed to a certain stage in clinical practice. When glaucoma, tumor compression and other optic nerve atrophy leads to visual impairment, it is also more difficult to improve through effective treatment, so early detection and early treatment is particularly important. Early detection, early intervention and early treatment are emphasized for all kinds of difficult-to-treat eye diseases, and it is recommended that patients with ocular discomfort consult a doctor in a timely manner to assess their condition and follow the doctor’s instructions for treatment.