Closed pimples, also known as whiteheads, look like yellowish-white dots or bumps. Closed pimples are clinically difficult to cure. Closed pimples occur because of a thick stratum corneum. Closed pimples are restless pimples (closed pimples) and can easily develop into blisters. Closed pimples are divided into closed pimples and blackheads. Most of the reasons for closed pimples on the face may be due to endocrine disorders caused by poor detoxification of the body. Closed acne is characterized by small, hard, white, hemispherical pimples the size of a grain of rice, with no conscious symptoms. The main reason for the formation of “acne” is the excessive secretion of androgens, especially in adolescent men and women. Androgens can directly stimulate the sebaceous glands to increase, promote the keratinization of hair follicles, block pores causing inflammation, resulting in acne and blisters. 2, related to the female physiological cycle, some women before the onset of menstruation, facial blisters intensify. It is mainly related to the change of hormone secretion. 3, Intrinsic body diseases or functional disorders, such as stomach, kidney, liver and other organ lesions, especially gastrointestinal dysfunction, constipation, etc. will induce acne. 4, mental tension, excessive fatigue, lack of sleep, etc. 5, over-eating greasy, sour and spicy and other stimulating food and sweet food. Second, external factors to form closed acne 1, improper cleaning: resulting in pore blockage, bacterial infection caused. 2, squeezing, picking, needle picking improper: some people have acne, squeezing caused by bacterial infection. 3, the application of poor quality cosmetics, such as dual-use powder, foundation, etc. 4, ultraviolet light and certain chemical substances, etc.